Biochemical Reagents, CHIR-99021, GSK3beta inhibitor, CAS 252917-06-9, 99% by TLC/NMR (conforms), Potent and selective inhibitor of glycogen synthase kinase-3beta (GSK3beta, IC50 5 nM) and GSK3alpha (IC50 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells2. Promotes replication and survival of pancreatic beta cells3.Enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors4. Cell permeable and active in vivo.